Association of Early-Life Cognitive Enrichment With Alzheimer Disease Pathological Changes and Cognitive Decline

Importance

Indicators of early-life cognitive enrichment (ELCE) have been associated with slower cognitive decline and decreased dementia in late life. However, the mechanisms underlying this association have not been elucidated.

Objective

To examine the association of ELCE with late-life Alzheimer disease (AD) and other common dementia-related pathological changes.

Design, Setting, and Participants

This...