Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study

Alzheimer's disease and its complications are the leading cause of death in adults with Down syndrome. Studies have assessed Alzheimer's disease in individuals with Down syndrome, but the natural history of biomarker changes in Down syndrome has not been established. We characterised the order and timing of changes in biomarkers of Alzheimer's disease in a population of adults with Down syndrome.We did a dual-centre cross-sectional study of...