Endocytic regulation of cellular ion homeostasis controls lysosome biogenesis
Abstract
Lysosomes serve as cellular degradation and signalling centres that coordinate metabolism in response to intracellular cues and extracellular signals. Lysosomal capacity is adapted to cellular needs by transcription factors, such as TFEB and TFE3, which activate the expression of lysosomal and autophagy genes. Nuclear translocation and activation of TFEB are induced by a variety of conditions such as starvation, lysosome stress and lysosomal...
Paper Details
Title
Endocytic regulation of cellular ion homeostasis controls lysosome biogenesis
Published Date
Jun 29, 2020
Journal
Volume
22
Issue
7
Pages
815 - 827
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