γ‑H2AX as a potential indicator of radiosensitivity in colorectal cancer cells

Preoperative radiotherapy improves local disease control and disease‑free survival in patients with advanced rectal cancer; however, a reliable predictive biomarker for the effectiveness of irradiation has yet to be elucidated. Phosphorylation of H2A histone family member X (H2AX) to γ‑H2AX is induced by DNA double‑strand breaks and is associated with the development of colorectal cancer (CRC). The current study aimed to clarify the relationship...