Up to 100-fold speed-up and multiplexing in optimized DNA-PAINT
Abstract
DNA-PAINT’s imaging speed has recently been significantly enhanced by optimized sequence design and buffer conditions. However, this implementation has not reached an ultimate speed limit and is only applicable to imaging of single targets. To further improve acquisition speed, we introduce concatenated, periodic DNA sequence motifs, yielding up to 100-fold-faster sampling in comparison to traditional DNA-PAINT. We extend this approach to six...
Paper Details
Title
Up to 100-fold speed-up and multiplexing in optimized DNA-PAINT
Published Date
Jun 29, 2020
Journal
Volume
17
Issue
8
Pages
789 - 791
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