COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis
Abstract
To investigate the immune response and mechanisms associated with severe coronavirus disease 2019 (COVID-19), we performed single-cell RNA sequencing on nasopharyngeal and bronchial samples from 19 clinically well-characterized patients with moderate or critical disease and from five healthy controls. We identified airway epithelial cell types and states vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In...
Paper Details
Title
COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis
Published Date
Jun 26, 2020
Journal
Volume
38
Issue
8
Pages
970 - 979
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