Precise, predictable multi-nucleotide deletions in rice and wheat using APOBEC–Cas9

Volume: 38, Issue: 12, Pages: 1460 - 1465
Published: Jun 29, 2020
Abstract
Short insertions and deletions can be produced in plant genomes using CRISPR-Cas editors, but reliable production of larger deletions in specific target sites has proven difficult to achieve. We report the development of a series of APOBEC-Cas9 fusion-induced deletion systems (AFIDs) that combine Cas9 with human APOBEC3A (A3A), uracil DNA-glucosidase and apurinic or apyrimidinic site lyase. In rice and wheat, AFID-3 generated deletions from...
Paper Details
Title
Precise, predictable multi-nucleotide deletions in rice and wheat using APOBEC–Cas9
Published Date
Jun 29, 2020
Volume
38
Issue
12
Pages
1460 - 1465
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