Impact of ISK Voltage and Ca2+/Mg2+-Dependent Rectification on Cardiac Repolarization
Abstract
Cardiac small conductance Ca2+-activated K+ (SK) channels are activated solely by Ca2+, but the SK current (ISK) is inwardly rectified. However, the impact of inward rectification in shaping action potentials (APs) in ventricular cardiomyocytes under β-adrenergic stimulation or in disease states remains undefined. Two processes underlie this inward rectification: an intrinsic rectification caused by an electrostatic energy barrier from...
Paper Details
Title
Impact of ISK Voltage and Ca2+/Mg2+-Dependent Rectification on Cardiac Repolarization
Published Date
Aug 1, 2020
Journal
Volume
119
Issue
3
Pages
690 - 704
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