Circadian asthma airway responses are gated by REV-ERBα

Background Asthma is an inflammatory disease of the airway showing a strong time of day rhythm. Airway hyperresponsiveness is a dominant feature of asthma, but it is not known if this is under clock control. The circadian clock powerfully regulates inflammation. The clock protein REV-ERBα is known to play a key role as a repressor of the inflammatory response. Objectives To determine if allergy mediated airway hyperresponsiveness is gated by the...