Discovery of a Cellular Mechanism Regulating Transcriptional Noise

Published: Jun 30, 2020
Abstract
Stochastic fluctuations in gene expression (‘noise’) are often considered detrimental but, in other fields, fluctuations are harnessed for benefit (e.g., ‘dither’ or amplification of thermal fluctuations to accelerate chemical reactions). Here, we find that DNA base-excision repair amplifies transcriptional noise, generating increased cellular plasticity and facilitating reprogramming. The DNA-repair protein Apex1 recognizes modified nucleoside...
Paper Details
Title
Discovery of a Cellular Mechanism Regulating Transcriptional Noise
Published Date
Jun 30, 2020
Journal
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