Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors
Abstract
Pancreatic neuroendocrine tumors (PanNET) were classified into grades (G) 1 to 3 by the World Health Organization in 2017, but the precise mechanisms of PanNET initiation and progression have remained unclear. In this study, we used a genetically engineered mouse model to investigate the mechanisms of PanNET formation. Although pancreas-specific deletion of the Rb gene (Pdx1-Cre;Rbf/f) in mice did not affect pancreatic exocrine cells, the...
Paper Details
Title
Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors
Published Date
Sep 1, 2020
Journal
Volume
80
Issue
17
Pages
3620 - 3630
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