A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination
Abstract
TMEM106B encodes a lysosomal membrane protein and was initially identified as a risk factor for frontotemporal lobar degeneration. Recently, a dominant D252N mutation in TMEM106B was shown to cause hypomyelinating leukodystrophy. However, how TMEM106B regulates myelination is still unclear. Here we show that TMEM106B is expressed and localized to the lysosome compartment in oligodendrocytes. TMEM106B deficiency in mice results in myelination...
Paper Details
Title
A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination
Published Date
Jun 23, 2020
Journal
Volume
143
Issue
7
Pages
2255 - 2271
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