Insights Into the Mechanism of MCT8 Oligomerization

Volume: 4, Issue: 8
Published: Jun 18, 2020
Abstract
Mutations in the thyroid hormone transporter monocarboxylate transporter 8 (MCT8) result in MCT8 deficiency, characterized by severe intellectual and motor disability. The MCT8 protein is predicted to have 12 transmembrane domains (TMDs) and is expressed as monomers, homodimers, and homo-oligomers. This study aimed to delineate the mechanism of MCT8 oligomerization. Coimmunoprecipitation studies demonstrated that lithium dodecyl sulfate...
Paper Details
Title
Insights Into the Mechanism of MCT8 Oligomerization
Published Date
Jun 18, 2020
Volume
4
Issue
8
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