Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity
Abstract
A contribution of epigenetic modifications to B cell tolerance has been proposed but not directly tested. Here we report that deficiency of ten-eleven translocation (Tet) DNA demethylase family members Tet2 and Tet3 in B cells led to hyperactivation of B and T cells, autoantibody production and lupus-like disease in mice. Mechanistically, in the absence of Tet2 and Tet3, downregulation of CD86, which normally occurs following chronic exposure of...
Paper Details
Title
Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity
Published Date
Jun 22, 2020
Journal
Volume
21
Issue
8
Pages
950 - 961
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