Structural insights into thebaine synthase 2 catalysis

Volume: 529, Issue: 2, Pages: 156 - 161
Published: Aug 1, 2020
Abstract
Thebaine synthase 2 (THS2) that can transform (7S)-salutaridinol 7-O-acetate to thebaine catalyzes the final step of thebaine biosynthesis in Papaver somniferum. Here, the crystal structures of THS2 and its complex with thebaine are reported, revealing the interaction network in the substrate-binding pocket. Subsequent docking and QM/MM studies was performed to further explore the catalytic mechanism of THS2. Our results suggest that T105 may...
Paper Details
Title
Structural insights into thebaine synthase 2 catalysis
Published Date
Aug 1, 2020
Volume
529
Issue
2
Pages
156 - 161
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