Identification of novel genes associated with dysregulation of B cells in patients with primary Sjögren’s syndrome

Background The aim of this study was to identify the molecular mechanism of dysregulation of B cell subpopulations of primary Sjögren’s syndrome (pSS) at the transcriptome level. Methods We enrolled patients with pSS ( n = 6) and healthy controls (HCs) ( n = 6) in the discovery cohort using microarray and pSS ( n = 14) and HCs ( n = 12) in the validation cohort using quantitative PCR (qPCR). Peripheral B cells acquired from these subjects were...