Multi-Step Ubiquitin Decoding Mechanism for Proteasomal Degradation
Abstract
The 26S proteasome is a 2.5-MDa protease complex responsible for the selective and ATP-dependent degradation of ubiquitylated proteins in eukaryotic cells. Proteasome-mediated protein degradation accounts for ~70% of all cellular proteolysis under basal conditions, and thereby any dysfunction can lead to drastic changes in cell homeostasis. A major function of ubiquitylation is to target proteins for proteasomal degradation. Accompanied by...
Paper Details
Title
Multi-Step Ubiquitin Decoding Mechanism for Proteasomal Degradation
Published Date
Jun 23, 2020
Journal
Volume
13
Issue
6
Pages
128 - 128
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