Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns

Volume: 11, Issue: 1, Pages: 1 - 16
Published: Jun 19, 2020
Abstract
Fragile X syndrome (FXS), a neurodevelopmental disorder, is a leading monogenetic cause of intellectual disability and autism spectrum disorder. Notwithstanding the extensive studies using rodent and other pre-clinical models of FXS, which have provided detailed mechanistic insights into the pathophysiology of this disorder, it is only relatively recently that human stem cell-derived neurons have been employed as a model system to further our...
Paper Details
Title
Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns
Published Date
Jun 19, 2020
Volume
11
Issue
1
Pages
1 - 16
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