Endogenous hydrogen sulfide improves vascular remodeling through PPARδ/SOCS3 signaling

Mounting evidences demonstrated the deficiency of hydrogen sulfide (H2S) facilitated the progression of cardiovascular diseases. However, the exact effects of H2S on vascular remodeling are not consistent.This study aimed to investigate the beneficial role of endogenous H2S on vascular remodeling.CSE inhibitor, DL-propargylglycine (PPG) was used to treat mice and vascular smooth muscle cells (VSMCs). Sodium hydrosulfide (NaHS) was given to...