Metabolomic and genetic associations with insulin resistance in pregnancy

Our study aimed to integrate maternal metabolic and genetic data related to insulin sensitivity during pregnancy to provide novel insights into mechanisms underlying pregnancy-induced insulin resistance. Fasting and 1 h serum samples were collected from women in the Hyperglycemia and Adverse Pregnancy Outcome study who underwent an OGTT at ∼28 weeks’ gestation. We obtained targeted and non-targeted metabolomics and genome-wide association data...