61-OR: Genetic and Metabolic Determinants of the Incretin Effect in Obese Adolescent with Prediabetes
Abstract
Prediabetes and type 2 diabetes in obese youths are associated with a reduced incretin effect. Herein, we investigated the metabolic and genetic determinants of incretin effect in obese youths with normal and impaired glucose tolerance. We studied 35 obese youth (15.8±2.4y, BMI 39.9±6.1kg/m2, NGT/IGT 18/17, F/M 18/17). All participants were genotyped for the TCF7L2 rs7903146 variant and underwent: A) 180-minutes OGTT and a matched iso-glycemic...
Paper Details
Title
61-OR: Genetic and Metabolic Determinants of the Incretin Effect in Obese Adolescent with Prediabetes
Published Date
Jun 1, 2020
Journal
Volume
69
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