Machine-Vision-Enabled Salt Dissolution Analysis
Abstract
Salt formation is a well-established method to increase the solubility of ionizable drug candidates. However, possible conversion of salt to its original form of free acid or base—disproportionation—can have a drastic effect on the solubility and consequently the bioavailability of a drug. Therefore, during the salt selection process, the salt dissolution behavior should be well understood. Improved understanding could be achieved by a method...
Paper Details
Title
Machine-Vision-Enabled Salt Dissolution Analysis
Published Date
Jun 16, 2020
Journal
Volume
92
Issue
14
Pages
9730 - 9738
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