IGF-1 and cardiometabolic diseases: a Mendelian randomisation study

Abnormal serum IGF-1 levels are associated with an increased risk of type 2 diabetes and cardiovascular disease. However, the causal role of IGF-1 levels within the normal range in cardiometabolic disease remains unclear. We employed Mendelian randomisation to explore the associations between genetically predicted serum IGF-1 levels and cardiometabolic diseases.Serum IGF-1 levels were predicted using 416 SNPs associated with IGF-1 levels among...