Janus nanoparticles with asymmetrically subcompartmentalized sensing and amplification modules toward fluorescence detection of microRNA
Abstract
The design and interfacial engineering of DNA functionalized nanosensors with spatially separated but functionally integrated detection units holds a great promise in optical biosensors. In this study, we developed a bi-component hybrid of Janus nanoquencher particles with immobilized enzymes for fluorescence-based “off-on” detection in solution. Specifically, the hybrids consisting of a mesoporous polydopamine nanoparticle (MPDA) side (∼200 nm)...
Paper Details
Title
Janus nanoparticles with asymmetrically subcompartmentalized sensing and amplification modules toward fluorescence detection of microRNA
Published Date
Oct 1, 2020
Volume
320
Pages
128438 - 128438
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