Alzheimer’s disease-related dysregulation of mRNA translation causes key pathological features with ageing
Abstract
Alzheimer's disease (AD) is characterised by Aβ and tau pathology as well as synaptic degeneration, which correlates best with cognitive impairment. Previous work suggested that this pathological complexity may result from changes in mRNA translation. Here, we studied whether mRNA translation and its underlying signalling are altered in an early model of AD, and whether modelling this deficiency in mice causes pathological features with ageing....
Paper Details
Title
Alzheimer’s disease-related dysregulation of mRNA translation causes key pathological features with ageing
Published Date
Jun 16, 2020
Journal
Volume
10
Issue
1
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