Parsing Psychiatric Heterogeneity Through Common and Unique Circuit-Level Deficits

It is increasingly recognized that progress in psychiatry is hindered by the heterogeneity of clinical diagnoses as codified by the DSM. Progress in other fields of medicine has in large part been predicated upon parsing clinical phenomena that appear similar into biologically homogeneous subtypes that align with prognosis and treatment response. At present, psychiatric diagnostic entities remain defined by clinical signs and symptoms and are...