Whole exome sequencing reveals the different responsiveness to Enterovirus 71 vaccination in Chinese children

PurposeTo explore the molecular genetic mechanisms underlying different responsiveness to Enterovirus 71 (EV71) vaccine.MethodsWe recruited 10,245 healthy children into a phase 3 clinical trial to evaluate the efficacy of EV71 vaccine in 2012. Fifty subjects from the trial were divided into the potent immune response group (20 subjects) and the ineffective immune response group (30 subjects). Whole-exome sequencing was performed for these 50...