Microbiome transfer between IL-1RI-/- and wild-type mice during high or low-fat feeding alters metabolic tissue functionality but not glucose homeostasis.
Abstract
Reduced inflammatory signaling ( IL-1RI -/- ) alters metabolic responses to dietary challenges (1) . Inflammasome deficiency (e.g. IL-18 -/- , Asc -/- ) can modify gut microbiota concomitant with hepatosteatosis; an effect that was transferable to wild-type (WT) mice by co-housing (2) . Taken together, this evidence suggests that links between diet, microbiota and IL-1RI-signaling can influence metabolic health. Our aim was to determine whether...
Paper Details
Title
Microbiome transfer between IL-1RI-/- and wild-type mice during high or low-fat feeding alters metabolic tissue functionality but not glucose homeostasis.
Published Date
Jan 1, 2020
Volume
79
Issue
OCE2
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