1261-P: OGTT Model–Derived ß-Cell Function Reveals Differential Loss in Youth vs. Adults during and following Treatment Withdrawal in the Restoring Insulin Secretion (RISE) Study

Loss of β-cell function is critical in the pathogenesis of T2D and may progress more rapidly in youth. We compared 3-hr OGTT model-derived measures of β-cell function in youth and adults with IGT or T2D in RISE treated for 12 mo with metformin (MET), or glargine followed by metformin (G/M) and 9 mo after treatment withdrawal. Model parameters included insulin sensitivity (OGIS), insulin secretion rate (ISR) at glucose 6.5 mM (ISR-6.5), total ISR...