Triethylenetetramine (trientine): a caloric restriction mimetic with a new mode of action
Abstract
Caloric restriction mimetics (CRMs) are nontoxic macroautophagy/autophagy enhancers that act through the stimulation of cytoplasmic protein deacetylation reactions. Thus far, three functional classes of CRMs have been described: inhibitors of acetyltransferases (such as spermidine), inhibitors of acetyl coenzyme (AcCoA) synthesis (such as hydroxycitrate) and activators of deacetylases/sirtuins (such as resveratrol). Triethylenetetramine (also...
Paper Details
Title
Triethylenetetramine (trientine): a caloric restriction mimetic with a new mode of action
Published Date
Jun 16, 2020
Journal
Volume
16
Issue
8
Pages
1534 - 1536
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History