Eicosapentaenoic acid attenuates renal lipotoxicity by restoring autophagic flux
Abstract
Recently, we identified a novel mechanism of lipotoxicity in the kidney proximal tubular cells (PTECs); lipid overload stimulates macroautophagy/autophagy for the renovation of plasma and organelle membranes to maintain the integrity of the PTECs. However, this autophagic activation places a burden on the lysosomal system, leading to a downstream suppression of autophagy, which manifests as phospholipid accumulation and inadequate acidification...
Paper Details
Title
Eicosapentaenoic acid attenuates renal lipotoxicity by restoring autophagic flux
Published Date
Jun 28, 2020
Journal
Volume
17
Issue
7
Pages
1700 - 1713
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