TargetingMETDysregulation in Cancer
Abstract
Aberrant MET signaling can drive tumorigenesis in several cancer types through a variety of molecular mechanisms including MET gene amplification, mutation, rearrangement, and overexpression. Improvements in biomarker discovery and testing have more recently enabled the selection of patients with MET-dependent cancers for treatment with potent, specific, and novel MET-targeting therapies. We review the known oncologic processes that activate...
Paper Details
Title
TargetingMETDysregulation in Cancer
Published Date
Jul 1, 2020
Journal
Volume
10
Issue
7
Pages
922 - 934
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