Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature
Abstract
Mutations in chromatin-modifying complexes and metabolic enzymes commonly underlie complex human developmental syndromes affecting multiple organs. A major challenge is to determine how disease-causing genetic lesions cause deregulation of homeostasis in unique cell types. Here we show that neural-specific depletion of three members of the non-specific lethal (NSL) chromatin complex-Mof, Kansl2 or Kansl3-unexpectedly leads to severe vascular...
Paper Details
Title
Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature
Published Date
Jun 15, 2020
Journal
Volume
22
Issue
7
Pages
828 - 841
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