Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis

Volume: 31, Issue: 7, Pages: 1479 - 1495
Published: Jun 15, 2020
Abstract
Genetic mutations in α-actinin-4 (ACTN4)-an important actin crosslinking cytoskeletal protein that provides structural support for kidney podocytes-have been linked to proteinuric glomerulosclerosis in humans. However, the effect of post-translational modifications of ACTN4 on podocyte integrity and kidney function is not known.Using mass spectrometry, we found that ACTN4 is phosphorylated at serine (S) 159 in human podocytes. We used...
Paper Details
Title
Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis
Published Date
Jun 15, 2020
Volume
31
Issue
7
Pages
1479 - 1495
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