Studies on spectral characterization and solubility of hydroxypropyl β-cyclodextrin/iloperidone binary and ternary complexes using different auxiliary agents

The antipsychotic drug Iloperidone (ILO) suffers from drawbacks of low solubility and poor bioavailability. In order to overcome such problems, we proposed to prepare binary and ternary complexes using kneading method and further compared for their ability to improve the solubility of ILO. Based on preliminary studies and phase solubility diagram, 1:1 ratio of drug and Hydroxypropyl β-cyclodextrin (HPβCD) was selected. Tartaric acid (TA) and...