53. Genomic characterization of brain metastases identifies drivers of metastatic lung adenocarcinoma

Brain metastases frequently arise from lung adenocarcinoma (BM-LUAD), yet the underlying genetic causes are poorly understood. In order to identify genomic alterations that promote brain metastases, we performed whole-exome sequencing of 73 BM-LUAD cases, and we developed a Gaussian Process Latent Difference model for discovering candidate metastatic drivers under a case-control study design. Using this statistical model, we discovered candidate...