Regulation of Mammalian Mitochondrial Dynamics: Opportunities and Challenges

Mitochondria are highly dynamic organelles and important for a variety of cellular functions. They constantly undergo fission and fusion events, referred to as mitochondrial dynamics, which affects the shape, size and number of mitochondria in the cell, as well as mitochondrial subcellular transport, mitochondrial quality control (mitophagy) and programmed cell death (apoptosis). Dysfunctional mitochondrial dynamics is associated with various...