1794-P: Successful Standardization of a Hyperglycemic Clamp Method across Multiple Clinical Centers in the Restoring Insulin Secretion (RISE) Study

In RISE, repeated measurements of β-cell function and insulin sensitivity were performed using a standardized hyperglycemic glucose clamp method. After in person training, clamps were performed at seven centers, in youth (Y) and adults (A) with impaired glucose tolerance (IGT) or early type 2 diabetes (T2D). The goal was to achieve and maintain a plasma glucose concentration of 200 mg/dL over 120 minutes using a priming bolus followed by a...