A single-cell transcriptomic atlas of primate pancreatic islet aging
Abstract
Aging-related degeneration of pancreatic islet cells contributes to impaired glucose tolerance and diabetes. Endocrine cells age heterogeneously, complicating the efforts to unravel the molecular drivers underlying endocrine aging. To overcome these obstacles, we undertook single-cell RNA sequencing of pancreatic islet cells obtained from young and aged non-diabetic cynomolgus monkeys. Despite sex differences and increased transcriptional...
Paper Details
Title
A single-cell transcriptomic atlas of primate pancreatic islet aging
Published Date
Jun 10, 2020
Journal
Volume
8
Issue
2
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