Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging

Volume: 62, Pages: 101097 - 101097
Published: Sep 1, 2020
Abstract
• Non-enzymatic modifications of extracellular matrix proteins is a missing hallmark of aging. • Damage of ECM triggers other hallmarks of aging and affects organ barriers integrity. • The promising interventions into aging can be AGE inhibitors, glucosepane breakers, and RAGE antagonists. Damage accumulation in long-living macromolecules (especially extracellular matrix (ECM) proteins, nuclear pore complex (NPC) proteins, and histones) is a...
Paper Details
Title
Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging
Published Date
Sep 1, 2020
Volume
62
Pages
101097 - 101097
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