Activating the DNA Damage Response and Suppressing Innate Immunity: Human Papillomaviruses Walk the Line
Abstract
Activation of the DNA damage response (DDR) by external agents can result in DNA fragments entering the cytoplasm and activating innate immune signaling pathways, including the stimulator of interferon genes (STING) pathway. The consequences of this activation can result in alterations in the cell cycle including the induction of cellular senescence, as well as boost the adaptive immune response following interferon production. Human...
Paper Details
Title
Activating the DNA Damage Response and Suppressing Innate Immunity: Human Papillomaviruses Walk the Line
Published Date
Jun 13, 2020
Journal
Volume
9
Issue
6
Pages
467 - 467
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