Kappa opioid receptors mediate an initial aversive component of paclitaxel-induced neuropathy
Abstract
Cancer patients receiving the antineoplastic drug paclitaxel report higher incidences and longer duration of treatment-resistant depression than patients receiving other classes of chemotherapeutics. Rodents treated with paclitaxel exhibit a suite of changes in affect-like behaviors. Further, paclitaxel causes chemotherapy-induced peripheral neuropathy (CIPN) in humans and rodents. Kappa opioid receptors (KOR) have a well-established role in...
Paper Details
Title
Kappa opioid receptors mediate an initial aversive component of paclitaxel-induced neuropathy
Published Date
Jun 11, 2020
Journal
Volume
237
Issue
9
Pages
2777 - 2793
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