Deconvolution of bulk blood eQTL effects into immune cell subpopulations
Abstract
Background Expression quantitative trait loci (eQTL) studies are used to interpret the function of disease-associated genetic risk factors. To date, most eQTL analyses have been conducted in bulk tissues, such as whole blood and tissue biopsies, which are likely to mask the cell type-context of the eQTL regulatory effects. Although this context can be investigated by generating transcriptional profiles from purified cell subpopulations, current...
Paper Details
Title
Deconvolution of bulk blood eQTL effects into immune cell subpopulations
Published Date
Jun 12, 2020
Journal
Volume
21
Issue
1
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