Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia

Volume: 11, Issue: 1
Published: Jun 12, 2020
Abstract
Activated protein C (APC) is a plasma serine protease with antithrombotic and cytoprotective functions. Based on the hypothesis that specific inhibition of APC’s anticoagulant but not its cytoprotective activity can be beneficial for hemophilia therapy, 2 types of inhibitory monoclonal antibodies (mAbs) are tested: A type I active-site binding mAb and a type II mAb binding to an exosite on APC (required for anticoagulant activity) as shown by...
Paper Details
Title
Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia
Published Date
Jun 12, 2020
Volume
11
Issue
1
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