Trifluridine/tipiracil in earlier lines of chemotherapy for advanced colorectal cancer

Trifluridine/tipiracil is an oral combination of agents currently approved for patients with advanced colon and gastric cancer progressing after several lines of treatment. Its use as a standard of care in patients progressing or intolerant to other anticancer agents was proven in phase III randomized trials1Mayer R.J. Van Cutsem E. Falcone A. et al.Randomized trial of TAS-102 for refractory metastatic colorectal cancer.N Engl J Med. 2015; 372:...