Population-based targeted sequencing of 54 candidate genes identifiesPALB2as a susceptibility gene for high-grade serous ovarian cancer
Abstract
The known epithelial ovarian cancer (EOC) susceptibility genes account for less than 50% of the heritable risk of ovarian cancer suggesting that other susceptibility genes exist. The aim of this study was to evaluate the contribution to ovarian cancer susceptibility of rare deleterious germline variants in a set of candidate genes.We sequenced the coding region of 54 candidate genes in 6385 invasive EOC cases and 6115 controls of broad European...
Paper Details
Title
Population-based targeted sequencing of 54 candidate genes identifiesPALB2as a susceptibility gene for high-grade serous ovarian cancer
Published Date
Jun 16, 2020
Journal
Volume
58
Issue
5
Pages
305 - 313
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