Human CRY1 variants associate with attention deficit/hyperactivity disorder

Volume: 130, Issue: 7, Pages: 3885 - 3900
Published: Jun 15, 2020
Abstract
Attention deficit/hyperactivity disorder (ADHD) is a common and heritable phenotype frequently accompanied by insomnia, anxiety, and depression. Here, using a reverse phenotyping approach, we report heterozygous coding variations in the core circadian clock gene cryptochrome 1 in 15 unrelated multigenerational families with combined ADHD and insomnia. The variants led to functional alterations in the circadian molecular rhythms, providing a...
Paper Details
Title
Human CRY1 variants associate with attention deficit/hyperactivity disorder
Published Date
Jun 15, 2020
Volume
130
Issue
7
Pages
3885 - 3900
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