Abstract A13: Neoadjuvant PD-1 mAb treatment induces postoperative immune memory responses against both immunodominant and immunorecessive antigens

Induction of T-cell responses to immunorecessive tumor antigens may be important for generation of polyclonal responses capable of eliminating immunoedited tumor cells that have lost immunodominant antigens. We hypothesized that neoadjuvant PD-1 mAb immune checkpoint inhibition (ICI) before surgery could induce polyclonal T-cell responses and lead to immunologic memory capable of preventing engraftment upon challenge with tumor cells lacking...