Synergistic gene editing in human iPS cells via cell cycle and DNA repair modulation

Volume: 11, Issue: 1
Published: Jun 8, 2020
Abstract
Precise gene editing aims at generating single-nucleotide modifications to correct or model human disease. However, precision editing with nucleases such as CRIPSR-Cas9 has seen limited success due to poor efficiency and limited practicality. Here, we establish a fluorescent DNA repair assay in human induced pluripotent stem (iPS) cells to visualize and quantify the frequency of DNA repair outcomes during monoallelic and biallelic targeting. We...
Paper Details
Title
Synergistic gene editing in human iPS cells via cell cycle and DNA repair modulation
Published Date
Jun 8, 2020
Volume
11
Issue
1
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