Placental Metabolomics for Assessment of Sex-specific Differences in Fetal Development During Normal Gestation

The placenta is a metabolically active interfacial organ that plays crucial roles in fetal nutrient delivery, gas exchange and waste removal reflecting dynamic maternal and fetal interactions during gestation. There is growing evidence that the sex of the placenta influences fetal responses to external stimuli in utero , such as changes in maternal nutrition and exposure to environmental stressors. However, the exact biochemical mechanisms...